The puppy vaccination series ends at approximately what age?

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Puppy vaccines are timed to overcome maternal antibodies and build solid, long-lasting protection. The usual schedule starts around 6–8 weeks and includes boosters every few weeks, so by the time the puppy reaches about 16 weeks, those exposures have allowed a reliable immune response to the vaccines. Maternal antibodies decline over time, and by 16 weeks the puppy’s immune system has typically seroconverted to the core vaccines, making the series effectively complete. After this point, boosters are given on a schedule (often annually or every three years, depending on the vaccine and local guidelines). Rabies is commonly started during this period as well, usually by 12–16 weeks, but the important takeaway for the end of the puppy series is that a solid, protective response is achieved around 16 weeks.